WORKING HOURS

7 Days a Week from 24 Hours

Edit
Online Resources
Learn more about different online health resources offered by Giostar India, including appointment, and more.
EXPRESS CARE ONLINE

Get a diagnosis and prescription virtually, from the comfort of your own home or office.

My Chart

View portions of your medical record, see test results, renew prescriptions and more.

My Consult

View portions of your medical record, see test results, renew prescriptions and more.

Microchimerism does not induce tolerance and sustains immunity after in utero transplantation

Donahue J, Gilpin E, Lee TH, Busch MP, Croft M, Carrier E. Transplantation. 2001 Feb 15;71(3):359-68.

Abstract

Background: To date, over 40 in utero transplants have been performed in humans; the only successes were documented in the treatment of severe combined immunodeficiency syndromes. Hemoglobinopathies and metabolic disorders are candidate diseases for this approach; however, when applied clinically, the results have been discouraging. To address the role of the fetal immune system in the outcome of in utero transplantation, we have developed a murine model of in utero transplantation in immunologically intact murine recipients and have studied chimerism and tolerance/immunity to allogeneic donor cells through the lives of the animals.

Methods: We have performed experiments in which purified murine sca-1+/lin- cells and c-kit+/lin- cells of C57BL/6 (H2b) mice were injected into Balb/c (H2d) fetal recipients at early gestational ages. 

Appointment Details