WORKING HOURS

7 Days a Week from 24 Hours

Edit
Online Resources
Learn more about different online health resources offered by Giostar India, including appointment, and more.
EXPRESS CARE ONLINE

Get a diagnosis and prescription virtually, from the comfort of your own home or office.

My Chart

View portions of your medical record, see test results, renew prescriptions and more.

My Consult

View portions of your medical record, see test results, renew prescriptions and more.

Resveratrol induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-kappaB activation to abrogate dextran sulfate sodium-induced colitis

Singh, U.P., Narendra P. Singh, Balwan Singh, Lorne J. Hofseth, Robert L Price,Mitzi Nagarkatti, and Prakash S. Nagarkatti (2010) Resveratrol (trans-3, 5, 4′- trihydroxystilbene) induces SIRT1 and down-regulates NF-kB activation toabrogate DSS-induced colitis. J. Pharmacology & Exp. Therapeutics. 332(3): 829-839.

Abstract

Inflammatory bowel disease is a chronic, relapsing, and tissue-destructive disease. Resveratrol, a naturally occurring polyphenol that exhibits beneficial pleiotropic health effects, is recognized as one of the most promising natural molecules in the prevention and treatment of chronic inflammatory disease and autoimmune disorders. In the present study, we investigated the effect of resveratrol on DSS-induced colitis in mice and found that it effectively attenuated overall clinical scores as well as various pathological markers of colitis. Resveratrol reversed the colitis-associated decrease in body weight and increased levels of serum amyloid A, tumor necrosis factor-alpha, interleukin (IL-6), and IL-1beta. After resveratrol treatment, the percentage of CD4(+) T cells in mesenteric lymph nodes (MLN) of colitis mice was restored to normal levels, and there was a decrease in these cells in the colon LP.

Appointment Details