Xiangli Cui, Yu Jin, Anne B. Hofseth, Alexander Chumanevich, Mitzi Nagarkatti,Prakash S. Nagarkatti, Udai P. Singh, and Lorne J. Hofseth (2010) Resveratrolsuppresses colitis and colon cancer associated with colitis. Cancer-Prevention Research. 3(4): 549-559.
Resveratrol is a naturally occurring polyphenol that exhibits pleiotropic health beneficial effects, including anti-inflammatory, cardio-protective, and cancer-protective activities. It is recognized as one of the more promising natural molecules in the prevention and treatment of chronic inflammatory and autoimmune disorders. Ulcerative colitis is an idiopathic, chronic inflammatory disease of the colon associated with a high colon cancer risk. Here, we used a dextran sulfate sodium (DSS) mouse model of colitis, which resembles human ulcerative colitis pathology. Resveratrol mixed in food ameliorates DSS-induced colitis in mice in a dose-dependent manner. Resveratrol significantly improves inflammation score, downregulates the percentage of neutrophils in the mesenteric lymph nodes and lamina propria, and modulates CD3(+) T cells that express tumor necrosis factor-alpha and IFN-gamma.