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Role of resveratrol-induced CD11b Gr-1 MDSCs in the reduction of CXCR3 T cells and amelioration of chronic colitis in IL-10 mice

Singh, U.P., Narendra P. Singh, Balwan Singh, Lorne J. Hofseth, Robert L Price, Mitzi Nagarkatti, and Prakash S. Nagarkatti. (2011) Role of resveratrol-induced CD11b+ Gr-1+ myeloid derived suppressor cells (MDSCs) in the reduction of CXCR3+ T cells and amelioration of chronic colitis in IL-10-/- mice. (Accepted in Brain, Behavior and Immunity).

Abstract

Resveratrol, a naturally occurring polyphenol has received significant attention as a potent anti-inflammatory agent. Inflammatory bowel disease (IBD) is a chronic intestinal inflammation caused by hyperactivated effector immune cells that produce proinflammatory cytokines. Myeloid derived suppressor cells (MDSCs) are a heterogeneous population characterized by the co-expression of CD11b(+) and Gr-1(+) and have long been known for their immunosuppressive function. We report that resveratrol effectively attenuated overall clinical scores as well as various pathological markers of colitis in IL-10(-/-) mice by down regulating Th1 responses. Resveratrol lessened the colitis-associated decrease in body weight and increased levels of serum amyloid A (SAA), CXCL10 and colon TNF-α, IL-6, RANTES, IL-12 and IL-1β concentrations.

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