7 Days a Week from 24 Hours

Edit Content
Online Resources
Learn more about different online health resources offered by Giostar India, including appointment, and more.

Get a diagnosis and prescription virtually, from the comfort of your own home or office.

My Chart

View portions of your medical record, see test results, renew prescriptions and more.

My Consult

View portions of your medical record, see test results, renew prescriptions and more.

Viral macrophage-inflammatory protein-II: a viral chemokine that differentially affects adaptive mucosal immunity compared with its mammalian counterparts

Singh U.P., S. Singh, R. Palaniappan, D.D. Taub, and J.W. Lillard, Jr. (2004) vMIP-II versus I-309 effects on adaptive immunity. Journal of Immunology 173:5509-5516.


Chemokines play a profound role in leukocyte trafficking and the development of adaptive immune responses. Perhaps due to their importance in host defense, viruses have adopted many of the hallmarks displayed by chemokines. In particular, viral MIP-II (vMIP-II) is a human chemokine homologue that is encoded by human herpes virus 8. vMIP-II is angiogenic, selectively chemotactic for Th2 lymphocytes, and a homologue of human I-309 and mouse TCA-3, which also differentially attracts Th2 cells. To better understand the effect of viral chemokines on mucosal immunity, we compared the affects of vMIP-II, I-309, and TCA-3 on cellular and humoral immune responses after nasal immunization with OVA. These CCR8 ligands significantly enhanced Ag-specific serum and mucosal Abs through increasing Th2 cytokine secretion by CD4+ T cells. These alterations in adaptive humoral and cellular responses were preceded (12 h after immunization) by an increase in CD4+ T and B cells in nasal tracts with decreases of these leukocyte populations in the lung.

Appointment Details