Our immune system protects us from foreign invading particles like bacteria and virus but cancer cells escape the immuno-surveillance due to self and non-foreign origin. Under progressive tumor conditions, immune system is suppressed and immune cells like dendritic cells fail to mature and generate anti-tumor activity. Cancer Immunotherapy is a treatment system where the immune system is activated to recognize and kill tumors inside body. Immunotherapy aims to target tumor cells without damaging the healthy ones and have very low or no toxicity. Dendritic cells are one of the important components of our immune system and play vital role in antigen presentation to body immune cells. Recent advances in immunotherapeutic area have led to the emergence of Dendritic cell based immunotherapeutics. It is a personalized cancer treatment comprising of patient’s own cells exposed to cancer antigens. These cells, when infuse back to patient, generate anti-tumor response. This technology can be applied to multiple cancers.