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Muscular Dystrophy:

Muscular Dystrophy can be classified as the disease with inborn genetic manipulation, which damage and weaken the muscular structure and strength over the period of time.

What Is Muscular Dystrophy?

Muscular Dystrophy can be classified as the disease with inborn genetic manipulation, which damage and weaken the muscular structure and strength over the period of time. It has been observed that the people with MD, have missing or incorrect information passed by their gene during the production of an important protein known as the “Dystrophin”; that is required for normal muscular functions of the body such as walking, swallowing, coordination, etc.
There are almost 30 different forms of Muscular Dystrophy that vary in symptoms, problems and severities. As the disease is related to muscular weakness, it can be possible that babies, teens or adults can express the muscular problems at any phase of their development. The severe form of MD, is observed in babies especially boys, who can experience the swift and severe muscle weakness and wasting; dying their late teens to early 20’s.
Muscular Dystrophy

Prevalence Of Muscular Dystrophy

Although, the number is still uncertain to know exactly how many people of all ages are suffering from the disease; an estimated 1 out of every 35000 males has Muscular Dystrophy. In a different study, it has been estimated that almost 29% of the men are using a wheelchair at the age of 9 years, 82% of the males are using the wheelchair support at the age of 14 years and more than 90% of them use the chair at the age of 24 years.
As far as the survival status is concerned, 100% of the boys were living at the age 9 years till the end of the study, 99% of men were living at the age of 14 years and 58% of them were living till their early 20’s.
There are almost 30 different Muscular Dystrophy variants, but nine forms of the MD are more commonly reported so far.

Factors Responsible For Muscular Dystrophy

Muscular Dystrophy is the genetic disorder due to faulty expression of mutated genes. Almost 90% of the disorders are being inherited from the family history whereas 10% of them are expressed due to spontaneous changes in their mothers egg or developing embryo that has been passed on to the next generation. A female who carries the faulty genes can pass the same on next generation. If the genes are being passed to the daughters, they become the carrier of the same whereas if the genes are being passed on to the boys they tend to express the symptoms.
Researcher could ultimately discover the abnormal gene which when defective can cause Muscular Dystrophy. The muscle protein associated with the gene abnormality is known as the Dystrophin. In some of the muscular dystrophy, the protein is being produced but it’s either not clear or is of very poor quality. However scientists are still working to discover the genetic defects causing other forms of the muscular dystrophy.

Symptoms Associated With MD

Muscular Dystrophy is the kind of a disease that cannot be diagnosed early in its progression; in fact some of the kids follow the normal pattern of development during first few years of their life. Slowly in time they start developing a problem in small things such as climbing staircase, walking on their toes, etc. A child may start to stumble, waddle or there may be a difficulty in getting up from the sitting position. A typical observation is that a child with MD, often develops enlarged calf muscles due to fat replacements.

Prognosis Of MD

A child has to first undergo a thorough physical examination followed by a detailed consultation on the family history. Some tests are also being suggested to conclude the type of MD, which has caused the problem. The doctor as well may suggest a blood check up to find out genetic problem.

What Goes Wrong In MD?

Muscular dystrophy is a type of neuromuscular disorder that progressively damages the healthy muscles causing them to be weak and wasted. The disease is a form of congenital abnormality due to wrong expression of faulty gene. Muscles and membrane need many different proteins to be strong and function properly. Some of these important proteins are being supplied to our body from the food we eat but some of them are actually synthesized by our own body such as Dystrophin. This information regarding the production as well as the amount of protein is being passed on, by our own genetic makeup. In people with muscular dystrophy, due to gene mutation wrong information is passed from one generation to another generation due to which these important proteins are produced or produced in very low quantities.
Without these proteins, muscles lose their structural and functional integrity slowly and progressively, which may affect the overall normal functioning of the body.

Stem Cell Treatment For Muscular Dystrophy

Muscles are the important fibrous connective tissue of the human body primarily involved in the movements in connection with the bones of the skeleton. They are responsible for beating of the heart, closing of eyelids and constitute the walls of the important organs. There are different types of muscles working in our body such as cardiac muscles, skeleton muscles and smooth muscles.
These muscles are the bundles of the packed cells known as muscle fibre cells. Due to different types of genetic manipulations, cells of the muscles are lost in neuromuscular degenerative diseases such as Muscular Dystrophy. There are some stored cells known as the stem cells or satellite cells which are responsible for production of dead muscle fibre cells to cope up with the damage. In case of MD, when cells are damaged, they activate these stem cells to form new muscle fibres or fuse with the existing cells to repair the damage. However, over the period of time the damage is so high that the reserved quota of stem cells is always not sufficient to manage.
Scientists have proved that our body has different sources of stem cells in different organs which are not being utilized by them. These sources of stem cells can now be exploited to isolate rich population of stem cells which when infused into the muscles can replace the damaged muscle cells with healthy muscular fibres and reduced the inflammation associated with the muscular dystrophy thereby slowing the progression of the disease.

Treatment Of MD At GIOSTAR

We have mastered the technology for isolating maximum number of viable stem cells from either the autologous sources of your own body or allogeneically with the matched donor to treat various forms of Muscular Dystrophy.
We are the licensed, private organization with the excellent, well equipped state of the art facility to isolate, process and enrich the viable number of stem cells, which can be re infused back into the patient’s body. Generally, these cells are administered through any one of the below mentioned methods depending upon our expert’s advice:


Through this mode, cell are infused directly in the muscles. .



Through this mode, cells are infused through the veins to expand blood volumes in the central nervous system, to ensure that the maximum number of cells are reaching to the targeted area. .

Once infused back in the body, these cells can reach at the targeted site through their strong paracrine effects and differentiate into lost muscle fibre cells or help revive the damaged ones to restore their function back.
Thus with our standardized, broad based and holistic approach, it is now possible to obtain noticeable improvements and stoppage of progression in the patients with progressive MD.

What Sets Us Apart


Disclaimer : Results may vary for each patient. GIOSTAR practice the application of stem cell therapy within the legal regulations of each country.